Oxidative Amidation of Aldehydes with Amines Catalysed by Fe(II) – Hydride Complex and N‐ Heterocyclic Carbenes (NHC)
Ashmita Singh, Chandra S. Azad, Anudeep Kumar Narula
Abstract
Abstract Oxidative amidation reaction of aldehydes with amines, by tert butyl hydrogen peroxide in toluene was achieved. The reaction utilised the in situ generated catalyst produced by Fe(II) – hydride complex [FeH 2 (PPh 3 ) 4 ], and N‐heterocyclic carbene (NHC) ligand. The catalytic system was found efficient for the synthesis of wide variety of mono and disubstiuted amides.
Topics & Concepts
CarbeneChemistryCatalysisHydrogen peroxideHydrideOxidative phosphorylationTolueneOxidative additionLigand (biochemistry)Medicinal chemistryOrganic chemistryCombinatorial chemistryHydrogenReceptorBiochemistryChemical Synthesis and AnalysisAsymmetric Hydrogenation and CatalysisSynthetic Organic Chemistry Methods