SCF/c-Kit-activated signaling and angiogenesis require Gαi1 and Gαi3
Huajian Shan, Kun Jiang, Ming-zhi Zhao, Wenjing Deng, Wen-hao Cao, Jiajun Li, Keran Li, Chang She, Wei-feng Luo, Jin Yao, Xiaozhong Zhou, Dan Zhang, Cong Cao
Abstract
increased significantly in the retinal tissues of streptozotocin-induced diabetic retinopathy (DR) mice. SCF silencing, through intravitreous injection of SCF shRNA AAV, inhibited pathological retinal angiogenesis and degeneration of retinal ganglion cells in DR mice. Finally, the expression of SCF and c-Kit increased in proliferative retinal tissues of human patients with proliferative DR. Taken together, Gαi1/3 mediate SCF/c-Kit-activated signaling and angiogenesis.
Topics & Concepts
AngiogenesisCell biologyProtein kinase BSmall hairpin RNAEctopic expressionGene knockdownGene silencingSignal transductionChemistryMolecular biologyBiologyCancer researchApoptosisBiochemistryGenePI3K/AKT/mTOR signaling in cancerCell Adhesion Molecules ResearchChemokine receptors and signaling