Enzymatic modification of<scp>d</scp>-mannose alleviates DSS-induced colonic inflammation in mice through macrophage polarization mediated by PPARγ
Yanjun Liu, Yanjun Liu, Ziwei Li, Yong‐Jiang Xu, Yuanfa Liu, Yuanfa Liu, Changhu Xue
Abstract
PPARγ activation. Concomitantly, in comparison with mice treated with D-mannose, the PtdMan treatment regimen showed therapeutic efficacy against colitis after 5 days of DSS induction. In summary, PtdMan showed the potential to reduce inflammation and ameliorate intestinal damage in DSS-induced colitis. These results indicate that PtdMan attenuates DSS-induced colitis and LPS-induced inflammation, and the mechanism behind the phenomenon may be regulating macrophage polarization. Our study provides a theoretical basis for phosphatidylmannoside to be used as a potential candidate for the treatment of colitis.
Topics & Concepts
InflammationMacrophage polarizationMannoseEnzymeChemistryMannose receptorMacrophagePeroxisome proliferator-activated receptorBiochemistryReceptorImmunologyBiologyIn vitroHelicobacter pylori-related gastroenterology studiesPancreatitis Pathology and TreatmentMacrophage Migration Inhibitory Factor