Flavonoid–amyloid fibril hybrid hydrogels for obesity control <i>via</i> the construction of gut microbiota

Abstract

was reversed. Furthermore, transplantation of the gut microbiota educated by the hydrogels to germ-free mice showed a substantial prevention effect on HFD-induced obesity, accompanied by a distinct microbiota structure that resisted HFD-induced divergence in microbiota structure. The flavonoid-amyloid fibril hydrogels inhibited the core molecular links between gut microbes and host intestinal lipid absorption, enhanced intestinal barrier function and reduced the abundance of bacterial taxa generating pro-inflammatory products, providing a general concept to design edible biomaterials for obesity prevention by targeting host-microbiota crosstalk.

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