Iron-catalyzed [3 + 2 + 1] annulation of 2-aminobenzimidazoles/3-aminopyrazoles and aromatic alkynes using N,N-dimethylaminoethanol as a one carbon synthon for the synthesis of pyrimido[1,2-a]benzimidazoles and pyrimido[1,2-b]indazoles

Zemin Qin, Ruiqin Zhang, Shenpeng Ying, Yongmin Ma

2022Organic Chemistry Frontiers30 citationsDOI

Abstract

A simple and efficient method for the synthesis of pyrimido[1,2- a ]benzimidazoles and pyrimido[1,2- b ]indazoles by a three-component [3 + 2 + 1] annulation catalyzed by FeCl 3 has been established.

Topics & Concepts

SynthonAnnulationChemistryCatalysisCombinatorial chemistryMedicinal chemistryOrganic chemistryCatalytic C–H Functionalization MethodsSynthesis and Biological EvaluationCatalytic Cross-Coupling Reactions

Iron-catalyzed [3 + 2 + 1] annulation of 2-aminobenzimidazoles/3-aminopyrazoles and aromatic alkynes using <i>N</i>,<i>N</i>-dimethylaminoethanol as a one carbon synthon for the synthesis of pyrimido[1,2-<i>a</i>]benzimidazoles and pyrimido[1,2-<i>b</i>]indazoles

Abstract

Topics & Concepts