Elastase-triggered H<sub>2</sub>S delivery from polymer hydrogels
Mingjun Zhou, Yun Qian, Yumeng Zhu, John B. Matson
Abstract
We report an elastase-responsive, H2S-releasing hydrogel prepared by covalently crosslinking a mixture of carboxymethylcellulose and poly(ethylene glycol) with an elastase-degradable peptide functionalized with an H2S-releasing S-aroylthiooxime (SATO) unit. Addition of elastase triggered a gel-to-sol transition, which exposed SATOs, leading to more and longer H2S release compared to untriggered gels.
Topics & Concepts
Self-healing hydrogelsElastasePolymerChemistryPolymer chemistryChemical engineeringEnzymeBiophysicsMaterials scienceBiochemistryOrganic chemistryBiologyEngineeringSulfur Compounds in BiologyObstructive Sleep Apnea ResearchNeuroscience of respiration and sleep