Hyperactive CDK2 Activity in Basal-like Breast Cancer Imposes a Genome Integrity Liability that Can Be Exploited by Targeting DNA Polymerase ε
Vladislav O. Sviderskiy, Lili M. Blumenberg, Elizabeth Gorodetsky, Triantafyllia Karakousi, Nicole Hirsh, Samantha Alvarez, Erdem M. Terzi, Efiyenia Ismini Kaparos, Gabrielle C. Whiten, Shakirah N. Ssebyala, Peter Tonzi, Hannan Mir, Benjamin G. Neel, Tony T. Huang, Sylvia Adams, Kelly V. Ruggles, Richard Possemato
Topics & Concepts
BiologyGenome instabilityDNA damageBreast cancerCancer researchCDC25ADNA repairDNA replicationCell cycleCell biologyCancerGeneticsDNACell cycle checkpointDNA Repair MechanismsGenomics and Chromatin DynamicsCancer-related Molecular Pathways