Synthesis of Cyclobutanes and Cyclobutenes by Strain-Release-Driven Ring-Opening of Bicyclo[1.1.0]butanes
Xuan Zhan, Heng-Xian He, Quanxin Peng, Jian‐Jun Feng
Abstract
Abstract Cyclobutanes and cyclobutenes exhibit intriguing structures and demonstrate significant biological activities and diverse synthetic applications. This review aims to summarize recent progress in strain-release-driven ring-opening reactions of bicyclo[1.1.0]butanes (BCBs) to synthesize these four-membered carbon rings. It outlines the strategies, regio- and stereoselectivity, the synthetic scope of reactions, and the mechanistic implications of the catalytic ring-opening process, providing a supplementary perspective to existing reviews. 1 Introduction 2 Thermally Driven Nucleophilic Ring-Opening 3 Thermally Driven Rearrangement and Isomerization Reaction 4 Light-Driven Ring-Opening 5 Transition-Metal/Lewis Acid Catalyzed Ring-Opening 6 Conclusion and Outlook