New metabolic signature for Chagas disease reveals sex steroid perturbation in humans and mice
Makan Golizeh, John Nam, Eric Chatelain, Yves Jackson, Leanne Ohlund, Asieh Rasoolizadeh, Fabio Vasquez Camargo, Louiza Mahrouche, Alexandra Fürtös, Lekha Sleno, Momar Ndao
Abstract
-infected mice, particularly in male animals. Proteomics analysis also found increased steroidogenesis in the testes of infected mice. Metabolic alterations identified in this study shed light on the pathogenesis and provide the basis for developing novel assays for the diagnosis and screening of CD patients.
Topics & Concepts
Chagas diseaseTrypanosoma cruziMetabolomicsPathogenesisMetabolomeBiologyDiseaseImmunologyInternal medicinePhysiologyBioinformaticsMedicineParasite hostingWorld Wide WebComputer scienceTrypanosoma species research and implicationsResearch on Leishmaniasis StudiesPharmacological Effects of Natural Compounds