UFMylation of MRE11 is essential for telomere length maintenance and hematopoietic stem cell survival
Lara Lee, Ana B. Pérez‐Oliva, Elena Martínez‐Balsalobre, Dmitri Churikov, Joshua Peter, Dalicya Rahmouni, Gilles Audoly, Violette Azzoni, Stéphane Audebert, Luc Camoin, Víctoriano Mulero, Maria L. Cayuela, Yogesh Kulathu, Vincent Géli, Christophe Lachaud
Abstract
-deficient zebrafish, demonstrating that UFMylation of MRE11 is a previously undescribed evolutionarily conserved mechanisms regulating telomere length.
Topics & Concepts
TelomereZebrafishBiologyPhenocopyCell biologyStem cellDNA repairPremature agingHaematopoiesisGeneticsDNAMutantGeneTelomeres, Telomerase, and SenescenceEpigenetics and DNA MethylationCongenital heart defects research