Silencing lncRNA AK136714 reduces endothelial cell damage and inhibits atherosclerosis
Jing Bai, Jianxia Liu, Zexian Fu, Yuanyuan Feng, Bing Wang, Wenjuan Wu, Ruiying Zhang
Abstract
assays showed that knockdown of AK136714 suppressed the inflammatory response and apoptosis in human umbilical vein endothelial cells (HUVECs). Moreover, AK136714 was found to bind directly to HuR to increase the mRNA stability of TNF-α, IL-1β and IL-6 mRNAs. In addition, AK136714 promoted the transcription of Bim. This study expands our understanding of the role of lncRNA AK136714 in atherosclerosis and provides potential drug targets for the treatment of atherosclerosis.
Topics & Concepts
Gene silencingGene knockdownUmbilical veinInflammationCancer researchApoptosisCoronary atherosclerosisLong non-coding RNASmall interfering RNAEndothelial stem cellEndothelial dysfunctionCellImmunologyBiologyCell biologyIn vitroMedicineCell cultureDownregulation and upregulationCoronary heart diseaseInternal medicineEndocrinologyTransfectionBiochemistryGeneGeneticsCancer-related molecular mechanisms researchAtherosclerosis and Cardiovascular DiseasesLipid metabolism and disorders