Targeting WEE1 by adavosertib inhibits the malignant phenotypes of hepatocellular carcinoma
Jian Chen, Xing Jia, Zequn Li, Wenfeng Song, Cheng Jin, Mengqiao Zhou, Haiyang Xie, Shusen Zheng, Penghong Song
Topics & Concepts
SorafenibHepatocellular carcinomaCancer researchCell cycleWee1Cell cycle checkpointApoptosisMitosisMitotic catastropheDNA damageCHEK1Cell growthG2-M DNA damage checkpointMedicineCancerBiologyInternal medicineCyclin-dependent kinase 1Cell biologyDNAGeneticsBiochemistryDNA Repair MechanismsPI3K/AKT/mTOR signaling in cancerMicrotubule and mitosis dynamics