DNAzyme-Based Lithium-Selective Imaging Reveals Higher Lithium Accumulation in Bipolar Disorder Patient-Derived Neurons
Claire E. McGhee, Zhenglin Yang, Weijie Guo, Yuting Wu, Mingkuan Lyu, Cynthia J. DeLong, Shanni Hong, Yuan Ma, Melvin G. McInnis, K. Sue O’Shea, Yi Lu
Abstract
in cells derived from BD patients compared with healthy controls in differentiated neurons but not NPCs. These results establish the DNAzyme-based sensor as a novel platform for biomedical research into BD and related areas using lithium drugs.
Topics & Concepts
Lithium (medication)DeoxyribozymeChemistryLithium metalProgenitor cellHeLaBipolar disorderCell biologyIn vitroBiophysicsBiologyStem cellBiochemistryEndocrinologyDNAPhysical chemistryElectrolyteElectrodeAdvanced biosensing and bioanalysis techniquesDNA and Nucleic Acid ChemistryRNA Interference and Gene Delivery