One year in review 2021: systemic sclerosis
Marco Di Battista, Simone Barsotti, Martina Orlandi, Gemma Lepri, Veronica Codullo, Alessandra Della Rossa, Serena Guiducci, Francesco Del Galdo
Abstract
Systemic sclerosis (SSc) is a connective tissue disease characterised by diffuse microangiopathy and immune dysregulation which ultimately results in widespread fibrosis of the skin and internal organs. This complex autoimmune disease is characterised by heterogeneous clinical manifestations and variable disease course in which the severity of pathology dictates the disease prognosis and course. Every year novel insights into the pathogenesis, organ involvement and treatment of this severe disease are published. Herewith, we provide an overview of the most significant literature contributions published last year, with the aim of helping the clinician in the understanding and management of SSc patients.