Harmonized standard operating procedures for administering the ALS functional rating scale-revised
Jeremy M. Shefner, Tommy M. Bunte, Gale Kittle, Angela Genge, Leonard H. van den Berg
Abstract
The ALS Functional Rating Scale-Revised is the most commonly used primary outcome measure in current ALS clinical trials. While rigorous training and certification is generally recognized as critical to reliable performance, differences have existed between training in the two groups responsible for most training in ALS outcome measures. We present a harmonized standard operating procedure which is intended to further reduce response variability by the use of identical training in North America and Europe.
Topics & Concepts
Rating scaleCertificationOutcome (game theory)Scale (ratio)Reliability engineeringPhysical medicine and rehabilitationPsychologyComputer scienceStatisticsMedicineMathematicsEngineeringCartographyMathematical economicsPolitical scienceLawGeographyAmyotrophic Lateral Sclerosis ResearchNeurogenetic and Muscular Disorders Research