2-Aminopyridines with a shortened amino sidechain as potent, selective, and highly permeable human neuronal nitric oxide synthase inhibitors
Dhananjayan Vasu, Huiying Li, Christine D. Hardy, T.L. Poulos, Richard B. Silverman
Topics & Concepts
ChemistryNitric oxide synthaseNitric oxideLipophilicityPotencySelectivityPharmacologyBlood–brain barrierBiochemistryIn vitroBiophysicsStereochemistryCentral nervous systemOrganic chemistryInternal medicineCatalysisMedicineBiologyNitric Oxide and Endothelin EffectsMetal-Catalyzed Oxygenation MechanismsElectron Spin Resonance Studies