Radical Hydro-Fluorosulfonylation of Propargylic Alcohols via Electron Donor–Acceptor Photoactivation
Yingyin Zhang, Qingyuan Feng, Yu Zheng, Yanju Lu, Saihu Liao, Shenlin Huang
Abstract
A radical hydro-fluorosulfonylation of propargyl alcohols with FSO 2 Cl is presented based on the photoactivation of the electron donor–acceptor (EDA) complex. The reaction avoids the requirement for photocatalysts, bases, hydrogen donor reagents, any other additives, and harsh conditions, enabling the facile synthesis of various functionalized γ-hydroxy ( E )-alkenylsulfonyl fluorides. These multifunctional sulfonyl fluorides can be further diversified, providing access to various privileged molecules of biological relevance.
Topics & Concepts
ChemistryReagentPropargylSulfonylElectron donorAcceptorElectron acceptorCombinatorial chemistryMoleculePhotochemistryOrganic chemistryCatalysisPhysicsAlkylCondensed matter physicsSulfur-Based Synthesis TechniquesFluorine in Organic ChemistryRadical Photochemical Reactions