LiBr-Catalyzed C3-Disulfuration between Indole and <i>N</i>-Dithiophthalimide
Dungai Wang, Wangyu Li, Keqiang Shi, Yuanjiang Pan
Abstract
-dithiophthalimides has been developed. This C-H disulfide reaction proceeded smoothly at room temperature with economical LiBr as catalyst, providing an effective method for the synthesis of novel unsymmetrical disulfides. A series of 3-dithioindole derivatives were obtained in high yields with good functional group tolerance; moreover, the wide scope of Harpp reagents (aryl, benzyl, primary, secondary, tertiary) confirmed the practicability of this approach.
Topics & Concepts
Indole testReagentFunctional groupCatalysisHalideArylCombinatorial chemistryDisulfide bondChemistryReaction conditionsMedicinal chemistryOrganic chemistryBiochemistryPolymerAlkylSulfur-Based Synthesis TechniquesChemical Synthesis and ReactionsSynthesis and Catalytic Reactions