Targeting gliomas with STAT3-silencing nanoparticles
Padma Kadiyala, Jason V. Gregory, Pedro R. Löwenstein, Joerg Lahann, María G. Castro
Abstract
Glioblastoma is an aggressive brain tumor with poor prognosis. The brain is protected by the blood-brain barrier, which precludes transport of chemotherapeutics. We developed nanoparticles that achieve delivery of small-interfering RNA against Stat3 after systemic administration. Nanoparticles combined with radiation inhibited tumor progression and elicited anti-glioblastoma immunity in mice.
Topics & Concepts
Small interfering RNAGliomaGlioblastomaBlood–brain barrierCancer researchBrain tumorGene silencingSystemic administrationSTAT3ImmunityMedicineRNAChemistryBiologyImmune systemImmunologyCentral nervous systemPathologyInternal medicineCell biologySignal transductionGeneIn vivoBiochemistryBiotechnologyCytokine Signaling Pathways and InteractionsMicroRNA in disease regulationCancer Mechanisms and Therapy