GPR43 activation-mediated lipotoxicity contributes to podocyte injury in diabetic nephropathy by modulating the ERK/EGR1 pathway
Jian Lü, Pei Pei Chen, Jia Xiu Zhang, Xue Qi Li, Gui Hua Wang, Ben Yin Yuan, Si Jia Huang, Xiao Qi Liu, Ting Jiang, Meng Ying Wang, Wen Tao Liu, Xiong Z. Ruan, Bi Cheng Liu, Kun Ling
Abstract
Background: G-protein-coupled receptor 43 (GPR43) is a posttranscriptional regulator involved in cholesterol metabolism. This study aimed to investigate the possible roles of GPR43 activation in podocyte lipotoxicity in diabetic nephropathy (DN) and explore the potential mechanisms.
Topics & Concepts
PodocyteLipotoxicityLDL receptorDiabetic nephropathyGene knockdownEndocrinologyInternal medicineCell biologyCholesterolAutophagyChemistryKidneyBiologyLipoproteinDiabetes mellitusBiochemistryApoptosisMedicineProteinuriaInsulin resistancePancreatic function and diabetesRenal Diseases and GlomerulopathiesChronic Kidney Disease and Diabetes