Bullous hemorrhagic Sweet syndrome with cryptococcoid neutrophils in patients positive for antineutrophil cytoplasmic antibody without primary vasculitis
Alex Sherban, Collin Fuller, Mansha Sethi, Eleni L. McGeehin, Dawn Hirokawa, Courtney Guerrieri, Jason Lee, Sherry Yang
Abstract
Sweet syndrome (SS) is a febrile neutrophilic dermatosis characterized by pyrexia, peripheral leukocytosis, and an abrupt onset of painful erythematous plaques and nodules.1,2 Lesions are typically found in an asymmetric distribution on the face, neck, and upper extremities and are often associated with an underlying malignancy, a systemic inflammatory condition, or a preceding infection.1,2 Histopathologic examination reveals a dense neutrophilic infiltrate with papillary dermal edema, and serum laboratory tests show leukocytosis, an elevated erythrocyte sedimentation rate, or both.
Topics & Concepts
MedicineLeukocytosisAnti-neutrophil cytoplasmic antibodyMalignancyPathologyErythrocyte sedimentation rateVasculitisSweet SyndromeEdemaSystemic vasculitisGastroenterologyImmunologyInternal medicineDiseaseAutoimmune and Inflammatory DisordersAutoimmune Bullous Skin DiseasesVascular Malformations and Hemangiomas