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Itraconazole and rifampicin, as CYP3A modulators but not P-gp modulators, affect the pharmacokinetics of almonertinib and active metabolite HAS-719 in healthy volunteers

Lu Liu, Wěi Li, Le Yang, Zitao Guo, Hao Xue, Ningjie Xie, Xiaoyan Chen

2021Acta Pharmacologica Sinica22 citationsDOIOpen Access PDF

Topics & Concepts

CYP3APharmacokineticsCmaxPharmacologyItraconazoleActive metaboliteMetaboliteIn vivoRifampicinChemistryOral administrationDrug interactionMetabolismMedicineBiologyCytochrome P450AntibioticsBiochemistryMicrobiologyAntifungalBiotechnologyLung Cancer Treatments and MutationsColorectal Cancer Treatments and StudiesPI3K/AKT/mTOR signaling in cancer
Itraconazole and rifampicin, as CYP3A modulators but not P-gp modulators, affect the pharmacokinetics of almonertinib and active metabolite HAS-719 in healthy volunteers | Litcius