Calorimetric Studies of Binary and Ternary Molecular Interactions between Transthyretin, Aβ Peptides, and Small-Molecule Chaperones toward an Alternative Strategy for Alzheimer’s Disease Drug Discovery
Ellen Y. Cotrina, Ana Gimeno, Jordi Llop, Jesús Jiménez‐Barbero, Jordi Quintana, Gregorio Valencia, Isabel Cardoso, Rafel Prohens, Gemma Arsequell
Abstract
). We propose the design of a simple assay system for the search of other chaperones that behave like IDIF and may become potential candidate drugs for Alzheimer's disease (AD).
Topics & Concepts
ChemistryTransthyretinDiflunisalIsothermal titration calorimetryDissociation constantTernary operationPeptideBiochemistryPharmacologyEndocrinologyReceptorProgramming languageMedicineComputer sciencethermodynamics and calorimetric analysesProtein Structure and DynamicsComputational Drug Discovery Methods