An mRNA vaccine candidate encoding H5HA clade 2.3.4.4b protects mice from clade 2.3.2.1a virus infection
S. Chiba, Maki Kiso, Shinya Yamada, Kazuhiko Someya, Yoshikuni Onodera, Aya Yamaguchi, Satoko Matsunaga, Ryuta Uraki, Kiyoko Iwatsuki‐Horimoto, Seiya Yamayoshi, Fumihiko Takeshita, Yoshihiro Kawaoka
Abstract
Highly pathogenic avian influenza (HPAI) H5 viruses from different clades have been circulating globally, threatening wild/domestic birds and mammals. Given frequent spillovers and high mortality among mammals, coupled with our inability to predict which clade of H5 virus has pandemic potential, cross-clade protective HPAI H5 vaccines are urgently needed. Here, we demonstrate the applicability of a lipid nanoparticle-based mRNA vaccine modality to induce cross-protective immunity against lethal HPAI virus infection.
Topics & Concepts
CladeVirologyVirusBiologyMessenger RNAGeneGeneticsPhylogeneticsInfluenza Virus Research StudiesAnimal Virus Infections StudiesViral gastroenteritis research and epidemiology