4th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 4)
Elżbieta Senkus, Bella Kaufman, Ian E. Krop, Nagi S. El Saghir, Frédérique Penault‐Llorca, Gertrude Nakigudde, Javier Cortés, Karen A. Gelmon, Fátima Cardoso, Maria João Cardoso, Baojun Xu, D.A. Vorobiof, Jonas Bergh, D. Warren Spence, Prudence A. Francis, Aleix Prat, Shani Paluch–Shimon, Sahil Koppikar, LA Carey, Christine B. Boers‐Doets, Christoph Thomssen, Laura Biganzoli, SR Johnston, Verena Ras, Eric P. Winer, Olivia Pagani, Giuseppe Curigliano, Musa Mayer, Alexandru Eniu, Hope S. Rugo, A. Costa, Matti Aapro, Fabrice André, Betzamel Lopez, Larry Norton, Shinji Ohno, Carlos H. Barrios, G. W. Sledge, Nadia Harbeck, Elektra J. Papadopoulos, Lesley Fallowfield, B.V. Offersen
Abstract
Advanced Breast Cancer (ABC) comprises both locally advanced breast cancer (LABC) and metastatic breast cancer (MBC) [1]. Although treatable, MBC remains virtually an incurable disease with a median overall survival (OS) of 3 years and a 5-year survival of only 25% [2, 3]. The MBC Decade Report [2] shows that progress has been slow in terms of improved outcomes, quality of life (QoL), awareness and information regarding ABC. More recently, some studies seem to indicate an improvement in OS, mostly due to advances in human epidermal growth factor receptor 2 (HER2)-positive ABC [4-6]. The better survival is seen in an environment with access to the best available care and particularly in de novo ABC, while recurrent ABC seems to become harder to manage [7, 8].