hnRNPU in Sertoli cells cooperates with WT1 and is essential for testicular development by modulating transcriptional factors <i>Sox8/9</i>
Yujiao Wen, Xixiang Ma, Xiaoli Wang, Fengli Wang, Juan Dong, Yanqing Wu, Chunyu Lv, Kuan Liu, Yan Zhang, Zhibing Zhang, Shuiqiao Yuan
Abstract
Our findings demonstrate an essential role of hnRNPU in Sertoli cells for prepubertal testicular development and testis microenvironment maintenance and define a new insight for our understanding of male infertility therapy.
Topics & Concepts
Sertoli cellFGF9BiologySOX9GonocyteCell biologyConditional gene knockoutGerm cellTranscription factorBlood–testis barrierInternal medicineEndocrinologyPhenotypeSpermatogenesisGeneGeneticsMedicineSperm and Testicular FunctionRenal and related cancersGenetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities