Competitive profiling of ligandable cysteines in <i>Staphylococcus aureus</i> with an organogold compound
Claudia Schmidt, Michael Zollo, Riccardo Bonsignore, Angela Casini, Stephan M. Hacker
Abstract
With the idea of exploiting metal templated C–S bond forming reactions to achieve modification of cysteines in bacterial proteins, a cyclometalated Au( iii ) compound was explored in a competitive chemoproteomic approach in S. aureus cell extracts.
Topics & Concepts
CysteineChemistryCovalent bondStaphylococcus aureusCombinatorial chemistryBacteriaCompetitive bindingEnzymeStereochemistryGroup 2 organometallic chemistryBiochemistryOrganic chemistryMoleculeReceptorGeneticsBiologyClick Chemistry and ApplicationsPeptidase Inhibition and AnalysisFerrocene Chemistry and Applications