New tetrahydro-isoquinoline derivatives as cholinesterase and α-glycosidase inhibitors: Synthesis, characterization, molecular docking & dynamics, ADME prediction, in vitro cytotoxicity and enzyme inhibition studies

I. G. Mamedov, Halil Şenol, Farid N. Naghiyev, Victor N. Khrustalev, Nastaran Sadeghian, Parham Taslımı

2024Journal of Molecular Liquids41 citationsDOI

Topics & Concepts

IsoquinolineChemistryCyclohexanoneStereochemistryDocking (animal)Molecular dynamicsCombinatorial chemistryComputational chemistryBiochemistryNursingMedicineCatalysisComputational Drug Discovery MethodsSynthesis and biological activityCholinesterase and Neurodegenerative Diseases

New tetrahydro-isoquinoline derivatives as cholinesterase and α-glycosidase inhibitors: Synthesis, characterization, molecular docking &amp; dynamics, ADME prediction, in vitro cytotoxicity and enzyme inhibition studies

Topics & Concepts

New tetrahydro-isoquinoline derivatives as cholinesterase and α-glycosidase inhibitors: Synthesis, characterization, molecular docking & dynamics, ADME prediction, in vitro cytotoxicity and enzyme inhibition studies