Opioids cause dissociated states of consciousness in C57BL/6J mice
Christopher OʼBrien, Clarence E. Locklear, Zachary T. Glovak, Diana Zebadúa Unzaga, Helen A. Baghdoyan, Ralph Lydic
Abstract
This study discovered that antinociceptive doses of fentanyl, morphine, and buprenorphine significantly and differentially disrupt EEG-defined states of consciousness in C57BL/6J mice. These data are noteworthy because: 1) buprenorphine is commonly used in medication-assisted therapy for opioid addiction, and 2) there is evidence that disordered sleep can promote addiction relapse. The results contribute to community phenotyping efforts by making publicly available all descriptive and inferential statistics from this study (Supplemental Tables S1–S8).
Topics & Concepts
Non-rapid eye movement sleepWakefulnessElectroencephalographyPsychologyOpioidNeuroscienceBuprenorphineNeuroscience of sleepSleep spindleAnesthesiaSleep (system call)MorphineMedicineInternal medicineReceptorOperating systemComputer scienceSleep and Wakefulness ResearchMemory and Neural MechanismsNeuroscience and Neuropharmacology Research