Optimization of uric acid detection with Au nanorod-decorated graphene oxide (GO/AuNR) using response surface methodology
Hana Safitri, Wulan Tri Wahyuni, Eti Rohaeti, Munawar Khalil, Frank Marken
Abstract
and AuNR volume of 10 mL. Under the optimum conditions, GO/AuNR/GCE showed acceptable analytical performance for UA detection with good linearity (concentration range of 10-90 μM) and both a low detection limit (0.4 μM) and quantitation limit (1.0 μM). Furthermore, the proposed sensor exhibits superior stability, reproducibility, and selectivity using ascorbic acid (AA), dopamine (DA), urea, glucose, and magnesium as interferents. Finally, practical use of GO/AuNR/GCE was demonstrated by successfully determining the content of UA in human urine samples with the standard addition approach.
Topics & Concepts
Detection limitAscorbic acidGrapheneNanorodMaterials scienceDifferential pulse voltammetryElectrodeComposite numberNuclear chemistryReproducibilityOxideElectrochemistryCyclic voltammetryChemistryNanotechnologyChromatographyMetallurgyComposite materialPhysical chemistryFood scienceElectrochemical sensors and biosensorsElectrochemical Analysis and ApplicationsConducting polymers and applications