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DJ-1 activates the AMPK/mTOR pathway by binding RACK1 to induce autophagy and protect the myocardium from ischemia/hypoxia injury

Xiao-Yan Zhao, Jianmin Ren, Huiru Liu, Tingting Zhou, Yuqin Wang, Song Liu, Heping Chen

2022Biochemical and Biophysical Research Communications12 citationsDOI

Topics & Concepts

AutophagyAMPKCardioprotectionPI3K/AKT/mTOR pathwayHypoxia (environmental)IschemiaIn vivoReperfusion injuryChemistryApoptosisMyocardial infarctionCell biologyPharmacologyPhosphorylationMedicineProtein kinase AInternal medicineBiologyBiochemistryOrganic chemistryOxygenBiotechnologyAutophagy in Disease and TherapyCalcium signaling and nucleotide metabolismElectrospun Nanofibers in Biomedical Applications
DJ-1 activates the AMPK/mTOR pathway by binding RACK1 to induce autophagy and protect the myocardium from ischemia/hypoxia injury | Litcius