Glucose homeostasis controls N-acetyltransferase 10-mediated ac4C modification of HK2 to drive gastric tumorigenesis
Qiang Wang, Mengmeng Li, Chen Chen, Lei Xu, Yao Fu, Jiawen Xu, Chuanjun Shu, Bo Wang, Zhangding Wang, Changyu Chen, Tao Song, Shouyu Wang
Abstract
Our findings highlight the critical crosstalk between glucose homeostasis and the ac4C epitranscriptome in gastric carcinogenesis. This finding offers a potential strategy of targeting NAT10/HK2 axis for the treatment of GC patients, especially those with highly active glucose metabolism.
Topics & Concepts
HomeostasisCarcinogenesisChemistryAcetyltransferaseCell biologyBiochemistryInternal medicineEndocrinologyBiologyCancer researchMedicineAcetylationGeneCancer, Hypoxia, and MetabolismAmino Acid Enzymes and MetabolismPancreatic function and diabetes