1,6-Addition of 1,2,3-NH triazoles to<i>para</i>-quinone methides: Facile access to highly selective N<sup>1</sup>and N<sup>2</sup>substituted triazoles
Vishakha Rai, P. Kavyashree, Sarvesh S. Harmalkar, Sundar N. Dhuri, Mahagundappa Rachappa Maddani
Abstract
Regioselective syntheses of N 1 and N 2 substituted triazoles via 1,6-addition of 1,2,3-NH triazole with p -QM were developed under mild reaction conditions. Isomerization of N 1 to N 2 substituted triazoles was also achieved in the presence of AlCl 3 .
Topics & Concepts
ChemistryRegioselectivityCombinatorial chemistrySelectivityQuinone methideReaction conditionsQuinoneSubstrate (aquarium)Medicinal chemistryOrganic chemistryCatalysisGeologyOceanographyClick Chemistry and ApplicationsSynthesis of Indole DerivativesMulticomponent Synthesis of Heterocycles