C–F Activation of Fluorinated Esters Using Photocatalytically Generated Diaminoalkyl Radical
Vladislav S. Kostromitin, Artem O. Sorokin, Vitalij V. Levin, Alexander D. Dilman
Abstract
A method for hydrofluoroalkylation of alkenes with trifluoroacetic esters under visible light irradiation affording difluorinated products is described. The reaction involves readily available trimethyltriazinane as a shoichiometric reducing agent, which generates a diamino-substituted alkyl radical serving as a strong electron donor. It is believed that the cleavage of the C-F bond by a triazinane-derived radical involves single electron reduction coupled with fluoride transfer.
Topics & Concepts
ChemistryTrifluoroacetic acidFluoridePhotochemistryAlkylCleavage (geology)Medicinal chemistryIrradiationRadical initiatorBond cleavageElectron transferOrganic chemistryCatalysisInorganic chemistryGeotechnical engineeringEngineeringPhysicsPolymerizationNuclear physicsFracture (geology)PolymerFluorine in Organic ChemistryRadical Photochemical ReactionsSulfur-Based Synthesis Techniques