C–H Alkylation of Cubanes via Catalytic Generation of Cubyl Radicals
M. Hosaka, Shota Nagasawa, Yoshiharu Iwabuchi
Abstract
A catalytic method for the C-H alkylation of cubanes is described. Some hydrogen atom transfer catalysts enable the direct abstraction of a hydrogen atom from the C-H bond of cubanes, followed by conjugate addition of the generated cubyl radicals to electron-deficient alkenes. Synthetic applications of the functionalization method developed are also described.
Topics & Concepts
ChemistryAlkylationRadicalCatalysisConjugateHydrogen atomHydrogen atom abstractionCombinatorial chemistrySurface modificationPhotochemistryOrganic chemistryGroup (periodic table)Physical chemistryMathematical analysisMathematicsRadical Photochemical ReactionsOxidative Organic Chemistry ReactionsCatalytic C–H Functionalization Methods