Pd-catalyzed imine-directed one-pot access to polysubstituted pyrroles<i>via</i>tandem triple isocyanide insertion/aza-Nazarov cyclization reactions
Jun Li, Zhi‐Wen Zhao, Shuang Zheng, Ping He, Ji‐Ying Qiu, Quan‐Quan Zhou, Zhi‐Lin Ren
Abstract
A novel one-pot method for synthesizing polysubstituted pyrrole derivatives via three-component reactions of alkenyl bromides, amines, and isocyanides is reported by Pd catalysis, without additional ligands, with the orderly insertion of three isocyanide molecules.
Topics & Concepts
ChemistryIsocyanideTandemImineCatalysisCombinatorial chemistryPyrroleMedicinal chemistryOrganic chemistryMaterials scienceComposite materialSynthesis and Characterization of PyrrolesCatalytic C–H Functionalization MethodsChemical Synthesis and Analysis