Lossen rearrangement by Rh(<scp>iii</scp>)-catalyzed C–H activation/annulation of aryl hydroxamates with alkynes: access to quinolone-containing amino acid derivatives
Dmitry A. Petropavlovskikh, Daria V. Vorobyeva, Ivan A. Godovikov, С.Е. Нефедов, Oleg A. Filippov, Sergey N. Osipov
Abstract
An efficient access to new CF 3 -containing 2-quinolones has been developed via Rh( iii )-catalyzed C–H activation/Lossen rearrangement/annulation cascade of N -pivaloyloxy-arylamides with internal alkynes bearing α-CF 3 -α-amino acid moiety on triple bond.
Topics & Concepts
ChemistryAnnulationMoietyArylCatalysisQuinoloneCombinatorial chemistryStereochemistryMedicinal chemistryOrganic chemistryBiochemistryAlkylAntibioticsCatalytic C–H Functionalization MethodsCyclopropane Reaction MechanismsFluorine in Organic Chemistry