C6–O-alkylated 7-deazainosine nucleoside analogues: Discovery of potent and selective anti-sleeping sickness agents
Fabian Hulpia, Jakob Bouton, Gustavo D. Campagnaro, Ibrahim A. Alfayez, Dorien Mabille, Louis Maes, Harry P. de Koning, Guy Caljon, Serge Van Calenbergh
Topics & Concepts
Trypanosoma bruceiChemistryPurine metabolismAfrican trypanosomiasisTrypanocidal agentPurineAlkylationNucleosideStereochemistryProdrugCytotoxicityBiochemistryIn vitroEnzymeTrypanosomiasisBiologyGeneVirologyCatalysisAdenosine and Purinergic SignalingHIV/AIDS drug development and treatmentTrypanosoma species research and implications