Reactive oxygen species-responsive polydopamine nanoparticles for targeted and synergistic chemo and photodynamic anticancer therapy
Gaole Dai, Jacky C. H. Chu, Cecilia Ka Wing Chan, Chung Hang Jonathan Choi, Dennis K. P. Ng
Abstract
cleavage of the thioketal linkages by the intrinsic intracellular reactive oxygen species (ROS). The stacked Pc molecules were then disaggregated, resulting in activation of their photosensitising property upon irradiation. The ROS generated by the activated Pc promoted further degradation of the nanoparticles and release of Dox, thereby enhancing cell death by synergistic chemo and photodynamic therapy. Systemic injection of PDA-Dox-Pc-QRH into EGFR-overexpressed tumour-bearing nude mice led to targeted delivery to the tumour, and subsequent light irradiation caused complete tumour ablation without inducing notable toxicity.
Topics & Concepts
Photodynamic therapyNanocarriersReactive oxygen speciesDoxorubicinIntracellularChemistryNanoparticlePhthalocyanineBiophysicsSinglet oxygenAnticancer drugOxygenNanotechnologyCancer researchMaterials scienceDrugPharmacologyBiochemistryMedicineBiologyChemotherapyOrganic chemistrySurgeryNanoplatforms for cancer theranosticsAdvanced Nanomaterials in CatalysisAdvanced Photocatalysis Techniques