Box–Behnken experimental design for optimizing the HPLC method to determine hydrochlorothiazide in pharmaceutical formulations and biological fluid
Sk Manirul Haque
Topics & Concepts
Box–Behnken designChromatographyResponse surface methodologyFactorial experimentHydrochlorothiazideFractional factorial designAcetonitrileMethanolVolumetric flow rateHigh-performance liquid chromatographyChemistryDesign of experimentsAnalytical Chemistry (journal)MathematicsMaterials scienceStatisticsMedicineQuantum mechanicsRadiologyPhysicsBlood pressureOrganic chemistryAnalytical Methods in PharmaceuticalsAnalytical Chemistry and ChromatographyAnalytical Chemistry and Sensors