Metabolomics analysis of urine from patients with alcohol-associated liver disease reveals dysregulated caffeine metabolism
Raobo Xu, Liqing He, Vatsalya Vatsalya, Xipeng Ma, Seongho Kim, Eugene G. Mueller, Wenke Feng, Craig J. McClain, Xiang Zhang
2022American Journal of Physiology-Gastrointestinal and Liver Physiology20 citationsDOIOpen Access PDF
Abstract
Our study using both untargeted and targeted metabolomics reveals the caffeine metabolic pathway is dysregulated in ALD. Three caffeine metabolites, 1-methylxanthine, paraxanthine, and 5-acetylamino-6-amino-3-methyluracil, can differentiate the severity of early-stage ALD.
Topics & Concepts
ParaxanthineCaffeineMetabolomicsUrineMetabolismPharmacologyMetabolomeChemistryMetabolic pathwayTheobromineAlcoholMedicineBiochemistryInternal medicineCYP1A2ChromatographyCytochrome P450Alcohol Consumption and Health EffectsCoffee research and impactsCannabis and Cannabinoid Research