Roles of the miR-139-5p/CCT5 axis in hepatocellular carcinoma: a bioinformatic analysis
Jingjing Xu, Yuan Zhang, Cheng Liu, Ping Yan, Zongguo Yang
Abstract
Background: MiRNAs are pivotal regulators involved in proliferation, apoptosis, invasion, metastasis, epithelial-mesenchymal transition (EMT), angiogenesis, drug resistance and autophagy in hepatocellular carcinoma (HCC). The aim of this study was to investigate the influence of miR-139-5p and its target genes on the outcomes of HCC. Methods: Survival analysis of miR-139-5p in HCC was conducted in Kaplan-Meier plotter. Target genes of miR-139-5p were identified in TargetScan, miRTarBase and starBase. Gene Expression Omnibus (GEO) series were used for the validation of miR-139-5p target genes. Cox proportional regression model was also established.
Topics & Concepts
Hepatocellular carcinomaProportional hazards modelmicroRNAOncologyCancer researchSurvival analysisPlotterMetastasisMedicineAngiogenesisBiomarkerGeneInternal medicineDownregulation and upregulationBiologyCancerBiochemistryComputer scienceOperating systemMicroRNA in disease regulationCircular RNAs in diseasesCancer-related molecular mechanisms research