Synthesis, Characterization, and Enzyme Inhibition Properties of 1,2,4-Triazole Bearing Azinane Analogues
Hafiz Muhammad Abdullah Asif, Shagufta Kamal, Azizur Rehman, Shahid Rasool, Muhammad Sajid Hamid Akash
Abstract
= 0.73 ± 0.54; 36.74 ± 1.24; 19.35 ± 1.28; 0.017 ± 0.53; and 0.038 ± 0.50 μM are found to be the most potent AChE, α-glucosidase, urease, and BChE inhibitors. The high inhibition potential of synthesized molecules against AChE, α-glucosidase, urease, and BChEenzymes inferred their role in enzyme inhibition properties.
Topics & Concepts
ChemistryPiperidineButyrylcholinesteraseAcetylcholinesteraseStereochemistryThiadiazolesArylElectrophileThio-BromideTriazoleAlkylEnzymeMedicinal chemistryAchéOrganic chemistryCatalysisSynthesis and biological activityClick Chemistry and ApplicationsSynthesis and Characterization of Heterocyclic Compounds