Catalytic Aerobic Dehydrogenatin of <i>N</i>‐Heterocycles by <i>N</i>‐Hydoxyphthalimide
Weidong Chen, Hao Tang, Weilin Wang, Qiang Fu, Junfei Luo
Abstract
Abstract Catalytic methods for the aerobic dehydrogenation of N ‐heterocycles are reported. In most cases, indoles are accessed efficiently from indolines using catalytic N ‐hydroxyphthalimide (NHPI) as the sole additive under air. Further studies revealed an improved catalytic system of NHPI and copper for the preparation of other heteroaromatics, for example quinolines. magnified image
Topics & Concepts
DehydrogenationChemistryCatalysisCopperCombinatorial chemistryOrganic chemistryMedicinal chemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsOxidative Organic Chemistry Reactions