Disturbed flow impairs MerTK-mediated efferocytosis in aortic endothelial cells during atherosclerosis
Jinzi Wu, Shijie Liu, Oishani Banerjee, Hang Shi, Bingzhong Xue, Zufeng Ding
Abstract
Our data suggests that blood flow patterns play an important role in regulating MerTK-mediated efferocytosis in aortic ECs, revealing a new promising therapeutic strategy with EC efferocytosis restoration to against atherosclerosis.
Topics & Concepts
EfferocytosisMERTKMedicineCardiologyInternal medicinePathologyChemistryMacrophageReceptorIn vitroReceptor tyrosine kinaseBiochemistryPhagocytosis and Immune RegulationImmune cells in cancerApelin-related biomedical research