Metal-, Photocatalyst-, and Light-Free Minisci C–H Acetylation of N-Heteroarenes with Vinyl Ethers
Jianyang Dong, Jianhua Liu, Hongjian Song, Yuxiu Liu, Qingmin Wang
Abstract
Herein, we report a mild, operationally simple method for Minisci C-H acetylation of N-heteroarenes using vinyl ethers as robust, inexpensive acetyl sources. The reactions do not require a conventional photocatalysis, electrocatalysis, metal catalysis, light activation, or high temperature. This method is thus significantly more sustainable than previously reported methods in terms of cost, reagent toxicity, and waste generation. This protocol can be expected to obtain medically relevant molecules from abundant feedstock materials.
Topics & Concepts
ChemistryReagentCatalysisPhotocatalysisMetalRaw materialAcetylationCombinatorial chemistryOrganic chemistryBiochemistryGeneCatalytic C–H Functionalization MethodsSulfur-Based Synthesis TechniquesRadical Photochemical Reactions