Reactions of Arsenoplatin-1 with Protein Targets: A Combined Experimental and Theoretical Study
Iogann Tolbatov, Damiano Cirri, Matteo Tarchi, Tiziano Marzo, Cecilia Coletti, Alessandro Marrone, Luigi Messori, Nazzareno Re, Lara Massai
Abstract
side chain models unveils that only neutral histidine and deprotonated cysteine and selenocysteine are able to effectively replace the chloride ligand in AP-1.
Topics & Concepts
ChemistrySelenocysteineHistidineLigand (biochemistry)CysteineStereochemistryElectrospray ionizationDeprotonationNucleophileMass spectrometryAmino acidBiochemistryOrganic chemistryEnzymeReceptorIonChromatographyCatalysisMetal complexes synthesis and propertiesEnzyme function and inhibitionLanthanide and Transition Metal Complexes