Evidence of Concurrent Light Chain and Transthyretin Cardiac Amyloidosis in 2 Patients
Joseph P. Donnelly, Andrej Gabrovsek, Lidiya Sul, Claudiu Cotta, E. René Rodríguez, Carmela D. Tan, Mazen Hanna
Abstract
Two distinct types of systemic amyloidosis, light chain (AL) and transthyretin (ATTR), account for >95% of diagnosed cardiac amyloidosis (CA) ([1][1]). AL arises from a clonal population of plasma cells that produce misfolded immunoglobulin light chains that aggregate in organs such as the heart,
Topics & Concepts
TransthyretinImmunoglobulin light chainAmyloidosisAmyloid fibrilAntibodyCardiac amyloidosisPopulationMedicineChemistryInternal medicineImmunologyEnvironmental healthDiseaseAmyloid βAmyloidosis: Diagnosis, Treatment, OutcomesEosinophilic Disorders and SyndromesParathyroid Disorders and Treatments