The Mycobacterial Efflux Pump EfpA Can Induce High Drug Tolerance to Many Antituberculosis Drugs, Including Moxifloxacin, in Mycobacterium smegmatis
Deepika Rai, Sarika Mehra
Abstract
from M. smegmatis, also led to decreased antimicrobial efficacy of many drugs, although the fold change was lower. When overexpressed in M. bovis BCG, 8-fold-higher drug tolerance to moxifloxacin was observed. This is the first report of an efflux pump from Mycobacterium species that leads to higher drug tolerance to moxifloxacin, a promising new drug for the treatment of tuberculosis.
Topics & Concepts
Mycobacterium smegmatisEffluxMicrobiologyMycobacterium tuberculosisBiologyMycobacteriumIsoniazidMoxifloxacinMycobacterium abscessusPharmacologyAntibioticsTuberculosisBacteriaMedicineBiochemistryGeneticsPathologyTuberculosis Research and EpidemiologyMycobacterium research and diagnosisAntibiotic Resistance in Bacteria