Design, synthesis, and biological evaluation of novel ciprofloxacin derivatives as potential anticancer agents targeting topoisomerase II enzyme
Hadeer K. Swedan, Asmaa E. Kassab, Ehab M. Gedawy, Salwa E. Elmeligie
Abstract
into the Topo II active site rationalised their remarkable Topo II inhibitory activity.
Topics & Concepts
DoxorubicinTopoisomeraseChemistryApoptosisCancer cellEnzymeCell cycleDocking (animal)StereochemistryCell culturePharmacologyBiochemistryCancerBiologyChemotherapyMedicineNursingGeneticsCancer therapeutics and mechanismsLung Cancer Research StudiesBioactive Compounds and Antitumor Agents